Table 3.
Effects of OPLE on renal structure
| |
Control |
Diabetes control |
Diabetes + OPLE 1000 mg kg
-1
|
|||
|---|---|---|---|---|---|---|
| 4 weeks | 12 weeks | 4 weeks | 12 weeks | 4 weeks | 12 weeks | |
| Glomerulosclerotic index |
0.23 ± 0.03 |
0.34 ± 0.03 |
1.14 ± 0.06a |
1.36 ± 0.04aa |
0.68 ± 0.06a,b |
1.62 ± 0.03aa |
| Tubulointerstitial fibrosis index | 0.49 ± 0.05 | 0.61 ± 0.06 | 2.48 ± 0.18a | 2.75 ± 0.16aa | 1.03 ± 0.08b | 3.05 ± 0.07aa |
Data are expressed as mean ± SEM of six experiments for each group. a P < 0.05; aa P < 0.01; vs. corresponding control; b P < 0.05, vs. corresponding diabetes control.