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. 2013 Aug 29;113(11):8546–8566. doi: 10.1021/cr400046x

Figure 3.

Figure 3

Phosphodiester bond addition cycle of S. cerevisiae RNAP II. Bridge helix is pink, trigger loop is green, NTP substrate is orange, RNA is purple, template DNA strand is blue, and nontemplate DNA strand is silver. The image is adapted from PDB files 2E2H (closed trigger loop) and 2E2J (open trigger loop). Reprinted with permission from ref (7a): Feig M.; Burton Z. F.. RNA polymerase II with open and closed trigger loops: Active site dynamics and nucleic acid translocation. Biophysical Journal 2010, 99(8), 2577.. Copyright 2010 Elsevier.