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SEM images of osteoblast-like cells (SaOS-2) cells cultured on nano-sized hydroxylapatite (nHAP)/collagen (Col) composites for 1 and 4 weeks. At 1 week, the cells well adhered to and spread on the surfaces of agglomerated n-HAP particles, and appeared as fibroblasts. At 4 weeks, the cells actively phagocytized the n-HAP particles, while extending many cellular projections, and appeared as spheroids. W, week.
