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. 2013 Nov 15;8(11):e79185. doi: 10.1371/journal.pone.0079185

Figure 2. Changes in sensitivity of the CBE test using cells transfected with different AQP4 isoforms.

Figure 2

Immunofluorescence analysis performed using NMO sera (NMO) and AQP4 commercial antibodies (AQP4) on cells transfected with AQP4-M23 (M23), WT AQP4-M1 (M1) and the mutated form of AQP4-M1 (M1M23I). The binding is very efficient for cells transfected with AQP4-M23, strongly recognized by NMO sera (collection of 20 NMO sera), whereas it is weak for cells transfected with AQP4-M1. No or very weak staining was detectable for cells transfected with M1M23I. Magnification bar, 10 µm.