Table 1. Summary of the results obtained in terms of sensitivity and specificity for testing sera by immunofluorescence on cells transfected with AQP4-M23 or AQP4-M1 (AQP4-M1>M23) or AQP4-M1 (M1M23I).

Patient sera(n = 112)	AQP4-M23 based test(M23 isoform)	AQP4-M1 based test(M1>M23)	AQP4-M1M23I based test(M1 isoform)
NMO (n = 40)	Positive: 39	Positive: 11	Positive: 0
Sensitivity	39/40 = 97.5% (95% CI: 87%–100%)	11/40 = 27.5% (95% CI: 15%–44%)	0/40 = 0% (95% CI: 0%–9%)
Other diagnosis andhealthy donors (n = 72)	Positive: 0	Positive: 0	Positive: 0
Specificity	72/72 = 100% (95% CI: 95%–100%)	72/72 = 100% (95% CI: 95%–100%)	72/72 = 100% (95% CI: 95%–100%)
Likelihood ratios	LR+: ∞; LR−: 0.025	LR+: ∞; LR−: 0.725	LR+: ∞; LR−: 1

Note that the sensitivity is 97.5% and specificity is 100%.