Table 2. NMO-IgG binding on AQP4-M23 with C- or N- terminal fluorescent tag.
Patient sera (n = 112) | Positive on M23-mCherry | Positive on GFP-M23 |
NMO (n = 40) | Positive: 39 | Positive: 0 |
Sensitivity | 39/40 = 97.5% (95% CI 87%–100%) | 0/0 = 0% (95% CI 0%–9%) |
Other diagnosis andhealthy donors (n = 72) | Positive = 0 | Positive = 0 |
Specificity | 72/72 = 100% (95% CI 95%–100%) | 72/72 = 100% (95% CI 95% 100%) |
Likelihood ratios | LR+: ∞; LR−: 0.025 | LR+: ∞; LR−: 1 |