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. 2013 Nov 15;8(11):e79185. doi: 10.1371/journal.pone.0079185

Table 2. NMO-IgG binding on AQP4-M23 with C- or N- terminal fluorescent tag.

Patient sera (n = 112) Positive on M23-mCherry Positive on GFP-M23
NMO (n = 40) Positive: 39 Positive: 0
Sensitivity 39/40 = 97.5% (95% CI 87%–100%) 0/0 = 0% (95% CI 0%–9%)
Other diagnosis andhealthy donors (n = 72) Positive = 0 Positive = 0
Specificity 72/72 = 100% (95% CI 95%–100%) 72/72 = 100% (95% CI 95% 100%)
Likelihood ratios LR+: ∞; LR−: 0.025 LR+: ∞; LR−: 1