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. 2013 Nov 15;8(11):e80645. doi: 10.1371/journal.pone.0080645

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© 2013 Honarnejad et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) The average peak amplitude of CCh-induced calcium release is significantly potentiated in FAD and inactive PS1 mutants compared to wild type PS1 cells (*** P<0.001). (b) The average number of responsive cells to CCh is remarkably increased in cells expressing FAD and inactive PS1 mutants compared to wild type PS1 cells (*** P<0.001).