Table 1. Kinase inhibition parameters.[a] .
IC50 (μM) | H | ||
Imatinib | 50 µM ATP | 0.040±0.004 | 0.71±0.05 |
500 µM ATP | 0.409±0.040 | 0.71±0.05 | |
Abltide | 50 µM ATP | 21.51±2.64 | 0.89±0.10 |
500 µM ATP | 37.47±3.95 | 1.80±0.31 |
Inhibitory concentration (IC50) and Hill slope (H) determined by fitting dose-response plots with a sigmoidal curve (see Figure 5).