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. 2013 Nov 15;8(11):e80885. doi: 10.1371/journal.pone.0080885

Figure 3. KP and KPI mice have high tumor burden, tumor cell proliferation and metastases.

Figure 3

Representative images of lungs (A and B), BrdU staining (C and D), pERK staining (E and F) and tumor metastases (G and H) from KP (A, C, E, and G) and KPI (B, D, F, and H) mice 12 weeks post-infection with adeno-Cre. Dotted lines (G and H) show metastastic tumor edges. Asterisks indicate center of metastatic tumors. Scale bar indicates 500 μm (A, B, G, and H), 50 μm (C and D) or 100 μm (E and F). Abbreviations: KP=Kras G12D ; p53 flox/flox. KPI=KrasG12D; p53flox/flox;IL-6-/-.