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. 2013 Oct 29;4:10–17. doi: 10.1016/j.nicl.2013.10.015

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© 2013 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Fig. 2 — Example images from a single RRMS subject: (a) baseline high-resolution T1-weighted MRI, (b) linearly registered follow-up high-resolution T1-weighted MRI, (c) output of SIENAX for baseline MRI with colored gray matter tissue, (d) SIENAX from the follow-up scan, outputs of SPM on baseline MRI (e) and follow-up MRI (f). The surface result of FreeSurfer on baseline MRI (g) and on follow-up MRI (h). Finally, from the Jacobian integration method, the absolute intensity difference maps, (i) = before and (j) = after nonlinear registration, and (k) color-coded Jacobian determinant map where red indicates voxel expansion and blue indicates contraction (range = ± 50%). A marked enlargement is visible in the ventricles and frontal sulcus (red) while overall parenchymal atrophy is visible in cortical gray matter and thalami (blue).