Table 1.
Comparison of various pipelines.
| Treatment effect | XPP + Jacobian integration | LPP + Jacobian integration | XPP + SPM | LPP + SPM | XPP + SIENAX | LPP + SIENAX | Cross-sectional FreeSurfer | Longitudinal FreeSurfer |
|---|---|---|---|---|---|---|---|---|
| 10% | 3201 (2129–4972) |
2731 (1996–3888) |
> 10,000 (7178–) |
7321 (4178–) |
> 10,000 (8143–) |
6174 (3638–) |
> 10,000 | > 10,000 |
| 20% | 801 (533–1244) |
684 (500–973) |
3496 (1796–9657) |
1832 (1045–3756) |
4336 (2037–) |
1545 (911–2990) |
> 10,000 (6339–) |
7084 (3184–) |
| 30% | 357 (238–554) |
305 (223–433) |
1,555 (799–4293) |
815 (465–1670) |
1928 (906–6764) |
687 (406–1330) |
> 10,000 (2818–) |
3148 (1416–) |
| 40% | 201 (134–312) |
172 (126–244) |
875 (450–2415) |
459 (262–940) |
1085 (510–3805) |
387 (229–748) |
5645 (1586–) |
1772 (797–6137) |
| 50% | 129 (87–200) |
111 (81–157) |
561 (289–1546) |
294 (169–602) |
695 (327–2436) |
248 (147–480) |
3613 (1016–) |
1134 (511–3928) |
| 60% | 90 (61–140) |
77 (57–109) |
390 (201–1074) |
205 (117–419) |
483 (228–1692) |
173 (102–333) |
2510 (706–) |
788 (355–2728) |
| 70% | 67 (45–103) |
57 (42–81) |
287 (148–790) |
151 (87–308) |
355 (168–1244) |
127 (76–245) |
1844 (519–) |
580 (261–2005) |
| 80% | 51 (35–79) |
44 (33–62) |
220 (114–605) |
116 (67–236) |
272 (129–952) |
98 (58–188) |
1412 (398–) |
444 (200–1535) |
| 90% | 41 (28–63) |
35 (26–49) |
174 (90–478) |
92 (53–187) |
215 (102–753) |
78 (46–149) |
1116 (314–) |
351 (159–1213) |
Required sample size per arm to detect treatment effect on cortical atrophy except for SPM, which uses gray matter atrophy. The range is a 95% confidence interval obtained from bootstrapping 10,000 times. Abbreviations: XPP = cross-sectional pre-processing; LPP = longitudinal pre-processing.