Table 2.
Significantly mutated genes in 87 hepatocellular carcinomas
| Gene | Description | # patients | # sites | Mutation significance (FDR q-val) |
|---|---|---|---|---|
| CTNNB1 | Beta-catenin | 20 | 14 | <1 × 10−11 |
| TP53 | Tumor protein p53 | 17 | 14 | <1 × 10−11 |
| CPA2 | Carboxypeptidase A2 (pancreatic) | 8 | 2 | 3.22 × 10−6 |
| IGSF3 | Immunoglobulin superfamily, member 3 | 8 | 5 | 1.3 × 10−5 |
| KEAP1 | Kelch-like ECH-associated protein 1 | 7 | 7 | 4 × 10−4 |
| ATAD3B | ATPase, AAA domain containing 3B | 4 | 2 | 2.6 × 10−3 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O- methyltransferase domain containing 1 | 3 | 2 | 8.3 × 10−3 |
| BRD9 | Bromodomain containing 9 | 5 | 2 | 0.017 |
| TTLL2 | Tubulin tyrosine ligase-like family, member 2 | 4 | 2 | 0.017 |
| TMEM170A | Transmembrane protein 170A | 3 | 1 | 0.037 |
| AR | Androgen receptor | 5 | 5 | 0.038 |
| TMEM51 | Transmembrane protein 51 | 3 | 1 | 0.042 |
| GJA1 | Gap junction protein, alpha 1, 43kDa | 3 | 3 | 0.049 |