Table 2. Cut points for System-level and Allostatic Load Scoring.
| Biomarkers by System | Cut Points |
|---|---|
| Cardiovascular | |
| Systolic blood pressure (mm Hg)a | ≥143 |
| Resting pulse pressure (mm Hg) | ≥65 |
| Resting heart rate (beats per minute)a | ≥77 |
| Glucose metabolism | |
| Blood glycosylated hemoglobin (%)a | ≥6.1 |
| Fasting blood glucose (mg/dL)a | ≥105 |
| Homeostasis model assessed insulin resistance | ≥4.04 |
| Lipid metabolism | |
| Body mass index (kg/m2) | ≥32.3 |
| Waist to hip circumference ratio | ≥0.97 |
| Low density lipoprotein cholesterol (mg/dL)a | ≥128 |
| High density lipoprotein cholesterol (mg/dL) | ≤41.4 |
| Serum triglycerides (mg/dL)a | ≥160 |
| Inflammation | |
| Serum C-reactive protein (mg/L) | ≥3.18 |
| Serum interleuken 6 (ng/L) | ≥3.18 |
| E-selectin (ng/mL) | ≥50.6 |
| Intracellular adhesion molecule-1 (mg/L) | ≥330 |
| Fibrinogen (mg/dL) | ≥390 |
| Hypothalamic-pituitary-adrenal axis | |
| Urine Cortisol (mg /g of creatinine) | ≥21.0 |
| Serum dehydroepiandrosterone sulfate (ug/dL) | ≤51.0 |
| Sympathetic nervous system | |
| Urine epinephrine (mg/g of creatinine) | ≥2.54 |
| Urine norepinephrine (mg/g of creatinine) | ≥33.3 |
| Parasympathetic (heart rate variability) | |
| Low frequency power (msec2) | ≤114 |
| High frequency power (msec2) | ≤54.2 |
| R-R interval standard deviation (msec) | ≤23.5 |
| Root mean square successive differences (msec) | ≤11.8 |
a
Scored as high-risk if taking medications that are generally prescribed to lower these risk factors, even if the measured biomarker is below the cut point.