Table 3. Adjusted associationsa of biology with cognition scores.
| Episodic Memory Score (N=1,072) |
Executive Function Score (N=1,076) |
|
|---|---|---|
| Allostatic load score (range 0-7, SD 1.14) | − 0.065** (−.113, −.017) | − 0.055* (−.100, −.010) |
|
| ||
| System-level scores (range 0-1) | ||
|
| ||
| Cardiovascular system score (SD 0.34) | − 0.25** (−.41, −.10) | − 0.17* (−.32, −.02) |
| Glucose metabolism score (SD 0.35) | − 0.13‡ (−.28, +.02) | − 0.20** (−.34, −.06) |
| Lipid metabolism score (SD 0.26) | − 0.11 (−.30, +.08) | − 0.19‡ (−.39, +.00) |
| Inflammation score (SD 0.26) | − 0.20* (−.39, −.01) | − 0.07 (−.24, +.11) |
| HPA axis score (SD 0.31) | + 0.05 (−.12, +.21) | + 0.02 (−.13, +.17) |
| Sympathetic system score (SD 0.35) | − 0.05 (−.20, +.10) | + 0.01 (−.12, +.14) |
| Parasympathetic system score (SD 0.36) | − 0.07 (−.21, +.07) | − 0.07 (−.21, +.06) |
Abbreviation: SD = Standard deviation; HPA = Hypothalamic-pituitary-adrenal
Results from separate models for allostatic load and each system score as primary predictor, adjusted for age (continuous, linear plus quadratic), sex, race (White vs. non-White), education (high school or less vs. some college vs. 4-year college graduate or more), parental education (continuous and high school or less vs. some college vs. 4-year college graduate or more), primary language (English vs. not), and neurological conditions (yes/no), and interactions for education with race, gender and age. Associations presented as point estimates (95% confidence limits). Confidence limits based on robust estimates of standard error that account for clustering within families.
p < 0.1;
p < 0.05;
p< 0.01