Table 2.

Longitudinal studies of risk of depression in the menopausal transition

Study	N	Baseline Mean Age	Stage
			Pre	Early Peri	Late Peri	Peri	Post
Depressive Symptoms
Bromberger et al, 2007a[47]	2885	46.4b	X	↑	↑		↑
Freeman et al, 2004c[48]	436	44.6d	X	↑	↑		ns
Depression Diagnosis
Cohen et al, 2006e [50]	460	36-46f	X			↑
Bromberger et al, 201g [46]	221	45.5 b	X			↑	↑

↑ indicates increased risk compared to premenopausal stage, ns indicates no significant difference

^aadjusted for site, baseline age, overall health and smoking status

^bpooled mean

^cadjusted for history of depression, severe premenstrual syndrome, poor sleep, age, race, employment status, hot flashes and FSH

^dage at end of 4 year follow-up

^eadjusted for age and proximate Life Experience Survey score

^fage reported in age-bands only

^gadjusted for age, race, history of major depression, annual psychotropic medication, annual very upsetting life events, and BMI