(A and B) At the pre-secretory stage, ameloblasts as well as stratum intermedium cells of both WT (A) and TgLRAP (B) mice strongly expressed SATB1 protein in the nucleus. (C and D) In the early secretory stage, SATB1 expression in the WT ameloblasts (C) remained strong in the nucleus similar to pre-secretory stage, but there was a marked decrease in the TgLRAP ameloblasts (D). (E and F) In the differentiated late secretory ameloblasts, SATB1 expression was reduced in the WT ameloblasts (E) compared to its earlier stage, and the corresponding stage of TgLRAP ameloblasts (F) demonstrated very weak expression. Scale bar, 20um.