Table 1.
Names and EuPathDB gene identification numbers for enzymes of fatty acid synthesis and modification pathways in representative kinetoplastids and apicomplexan parasites.
| T. brucei | L. major | P. falciparum | T. gondii | ||
|---|---|---|---|---|---|
| ELO pathway | |||||
| ELO1 | Fatty acid elongase A | Tb927.7.4180 | Lmjf.14.0640 Lmjf.14.0650 Lmjf.14.0660 | PF3D7_0920000 | TGME49_042380 |
| ELO2 | Fatty acid elongase B | Tb927.7.4170 | Lmjf.14.0670 | PF3D7_0605900 | TGME49_005350 |
| ELO3 | Fatty acid elongase C | Tb927.7.4160 | Lmjf.14.0680 Lmjf.14.0690 | PF3D7_0109300 | TGME49_053880 |
| ELO4 | Fatty acid elongase D | Tb927.5.4530 | Lmjf.05.1170 | - | - |
| KCR | Ketoacyl CoA reductase | Tb927.5.1210 | LmjF.34.0010 | PF3D7_0422000 | TGME49_071890 |
| HCD | Hydroxyacyl CoA reductase | Tb927.10.10610 | LmjF.05.0280 | PF3D7_1331600 | TGME49_111290 |
| ECR | Enoyl CoA reductase | Tb927.3.1840 | LmjF.25.1770 | PF3D7_1135900 | TGME49_085240 |
| FASII pathway | |||||
| ACP | Acyl carrier protein | Tb927.1.2100 | LmjF.27.0290 | PF3D7_0208500 | TGME49_064080 |
| KAR | Ketoacyl ACP reductase | Tb927.2.5210 | LmjF27.2440 | PF3D7_0922900 | TGME49_017740 |
| HAD | Hydroxyacyl ACP dehydratase | Tb927.8.1440 | LmjF07.0430 LmjF07.0440 | PF3D7_1323000 | TGME49_121570 |
| EAR | Enoyl ACP reductase | Tb927.10.11930 | LmjF.04.0290 | PF3D7_0420200 | TGME49_051930 |
| PPTase | Phosphopantetheinyl transferase | Tb927.3.1840 | LmjF.25.1770 | PF3D7_0420200 | TGME49_003420 |
| FASI pathway | |||||
| FASI | Fatty acid synthase type I | - | - | - | TGME49_094820 |
| PPTase | Phosphopantetheinyl transferase | - | - | - | TGME49_014440 |