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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: Chem Res Toxicol. 2013 Jun 13;26(7):1108–1114. doi: 10.1021/tx4001495

Figure 2.

Figure 2

Mutagenic bypass of MeFapy-dG: proposed primer-template misalignment models. With sequences 5–9, a subset of G to T transversions, the commonly observed base substitutions, could be generated by a primer-template misalignment-realignment (model I). Additional mechanism leading to G to T transversions could involve a non-instructive dA insertion opposite the lesion site and is not shown in this scheme. In the template slippage model (II-b), alternative slippage intermediates are possible.