Table 4. Effect of metronidazole resistance on 10 and 14 day sequential and 14 day triple therapies.
| Treatment | 10 d sequential | 14 d sequential | 14 d triple | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Scenario | Metronidazole resistance >20%; clarithromycin resistance=0 | Metronidazole resistance=20%; clarithromycin resistance=18% | Metronidazole resistance=30%; Clarithromycin resistance=6% | Metronidazole resistance = N/A Clarithromycin resistance=15% | ||||||||
| Pattern1 | Succ2 | %3 | #4 | Succ | % | # | Succ | % | # | Succ | % | # |
| Cs-Ms | 95% | 80 | 76 | 99% | 65.6 | 65 | 99% | 65.8 | 65 | 97% | 85 | 82.5 |
| Cr-Ms | 80% | 0 | 0 | 88% | 14.4 | 12.6 | 88% | 4.2 | 3.7 | 50% | 15 | 7.5 |
| Cs-Mr | 75% | 20 | 15 | 75% | 16.4 | 12.3 | 75% | 28.2 | 21 | n/a | - | --- |
| Cr-Mr | 10% | 0 | 0 | 15% | 3.6 | 0.5 | 15% | 1.8 | 0.3 | n/a | - | --- |
| Overall success | 91 | 90.4 | 90 | 90 | ||||||||
1
= Resistance pattern in population ranging from clarithromycin susceptible (Cs) and metronidazole susceptible (Ms) to dual resistance (Cr-Mr)
2
= Predicted treatment success for the pattern of resistance
3
= Percent of the study population with that pattern of resistance
4
= Success rate percent of the resistant pattern group with successful therapy