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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Trends Cardiovasc Med. 2013 Jul 1;24(1):10.1016/j.tcm.2013.05.004. doi: 10.1016/j.tcm.2013.05.004

Figure 1. Possible mechanisms of calcineurin-dependent regulation of cardiac LTCC.

Figure 1

(A) Calcineurin dephosphorylates the LTCC. The cognate kinase and specific enzymatic site(s) are currently undetermined. (B) Calcineurin mechanically alters LTCC function by direct protein-protein binding and conformational change. (C) Calcineurin interferes with PP2A interaction with LTCC. (D) Calcineurin alters LTCC function by activation of an intermediary protein(s). The identity of the downstream signaling target is currently unresolved. Key: α11.2 = LTCC pore-forming α subunit, CnA = calcineurin A catalytic subunit, P = phosphate, PP2A = protein phosphatase 2A, XYZ = unknown downstream target of calcineurin.