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. Author manuscript; available in PMC: 2015 Apr 4.
Published in final edited form as: Neuroscience. 2013 Jan 30;0:112–130. doi: 10.1016/j.neuroscience.2013.01.041

Figure 2. Prototypical small-molecule probes targeting epigenetic mechanisms with effects on moodrelated behavior.

Figure 2

Lysine deacetylase inhibitors affect nuclear and non-nuclear members of the zinc-dependent family of histone deacetylases (HDACs). DNMT inhibitors affect DNA methylation through integration into DNA (zebularine) or direct inhibition of DNMTs (RG108).