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. 2013 Nov 20;134(3):645–653. doi: 10.1002/ijc.28378

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© 2013 The Authors. Published by Wiley Periodicals, Inc. on behalf of UICC.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Correlation between cellular and plasma EBV levels for healthy and eBL children. There was a significant correlation between cellular and plasma EBV levels in healthy Kenyan children from Nyanza (triangle) r = 0.177, p-value = 0.010. Children diagnosed with eBL had a nonsignificant correlation coefficient of r = 0.243, p-value = 0.05 (open circles). Based on the area under the ROC curve to assess sensitivity and specificity, dashed lines at 2-log EBV copies per microliter of plasma and 3-log EBV copies per microgram of human DNA were selected to visualize viral loads in healthy Kenyan children (triangle) and eBL patients (open circles) as a proposed threshold if either were used as a biomarker. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]