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Infarct size (IS), expressed as a percentage of risk area, in nonischemic control (NIC), ischemic control (IC), preconditioned (PRE), postconditioned (POS), PRE + W (wortmannin), POS + W, lithium, and IMI treated hearts. Observe that all interventions decreased the infarct size detected in IC hearts. W abolished the protection achieved by PRE and POS. *P < 0.05 versus IC; # P < 0.05 versus PRE and POS.
