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. 2013 Oct 30;2013:317456. doi: 10.1155/2013/317456

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Copyright © 2013 Luisa F. González Arbeláez et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Representative immunoblots a of total and phosphorylated forms and summary of densitometry data of phospho-GSK-3β (P-GSK-3β, (a)) and phospho-Akt (P-Akt, (b)) level in mitochondrial fraction in nonischemic control (NIC), ischemic control (IC), preconditioned (PRE), postconditioned (POS), PRE + W (wortmannin), POS + W, lithium, and IMI treated hearts. VDAC was used as control. IC hearts showed high levels of cytosolic P-GSK-3β/GSK-3β and P-Akt/Akt ratios and they were significantly decreased by all the interventions. W annulled the effects of PRE and POS. *P < 0.05 versus NIC; ^# P < 0.05 versus IC; ^ξ P < 0.05 versus PRE and POS.