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Clinical trials characteristics and results of the association of donepezil plus memantine in moderate-severe AD.
| First author and no. in the list of references | Severity | Mean age years | Mean MMSE at baseline | Duration of the study | N | Test |
|---|---|---|---|---|---|---|
| Howard et al. 2012 [29] | MMSE 5–13 | 77.1 ± 8 | 9.1 ± 2.6 | 52 weeks | 295 | MMSE BADLS NPI PROXY |
|
| ||||||
| Doody et al. 2012 [30] | MMSE 0–20 | Memantine: 73.6 (8.63) Placebo: 74.0 (8.48) |
13.8 (4.63) | 24 weeks | 1436 | MMSE CIBIC-plus ACDS-ADL-sev SIB |
