Table III.
Regional clusters showing a significant association between cognitive performance and FA
| Hemisphere | Cluster size (mm3) | Minimum P‐value (10−x) | Weight | |
|---|---|---|---|---|
| TMT A | ||||
| Frontal | ||||
| Precentral | LH | 840 | 4.76 | 3998.40 |
| Lateral orbitofrontal | LH | 1080 | 3.18 | 3434.40 |
| Pars triangularis | RH | 584 | 3.09 | 1804.56 |
| Superior frontal | LH | 572 | 3.14 | 1796.08 |
| Rostral middle frontal | RH | 476 | 2.54 | 1209.04 |
| Precentral | RH | 360 | 2.66 | 957.60 |
| Pars opercularis | RH | 344 | 2.30 | 791.20 |
| Pars opercularis | LH | 376 | 2.00 | 752.00 |
| Parietal | ||||
| Superior parietal | LH | 944 | 3.40 | 3209.60 |
| Superior parietal | RH | 896 | 3.26 | 2920.96 |
| Postcentral | RH | 360 | 2.58 | 928.80 |
| Temporal | ||||
| Superior temporal | LH | 698 | 3.52 | 2456.96 |
| Inferior temporal | RH | 336 | 3.98 | 1337.28 |
| Superior temporal | RH | 336 | 2.53 | 850.08 |
| Inferior temporal | LH | 360 | 2.15 | 774.00 |
| Occipital | ||||
| — | — | — | — | — |
| Other | ||||
| Anterior corona radiata | LH | 2192 | 3.65 | 8000.80 |
| Genu corpus callosum | — | 628 | 2.71 | 1701.88 |
| Superior corona radiata | RH | 352 | 3.01 | 1059.52 |
| Body corpus callosum | — | 328 | 2.43 | 797.04 |
| TMT B | ||||
| Frontal | ||||
| Rostral middle frontal | RH | 400 | 4.81 | 1924.00 |
| Lateral orbitofrontal | RH | 520 | 2.93 | 1523.60 |
| Precentral | LH | 424 | 3.36 | 1424.64 |
| Superior frontal | LH | 364 | 2.84 | 1033.76 |
| Parietal | ||||
| Postcentral | RH | 1020 | 4.60 | 4692.00 |
| Precuneus | RH | 848 | 3.87 | 3281.76 |
| Inferior parietal | RH | 592 | 3.22 | 1906.24 |
| Superior parietal | RH | 508 | 3.05 | 1549.40 |
| Temporal | ||||
| Superior temporal | RH | 516 | 3.13 | 1615.08 |
| Occipital | ||||
| — | — | — | — | — |
| Other | ||||
| Fornix stria terminalis | RH | 1000 | 3.38 | 3380.00 |
| Anterior limb of the internal capsule | RH | 784 | 2.47 | 1936.48 |
| Anterior limb of the internal capsule | LH | 424 | 2.58 | 1093.92 |
| Superior longitudinal fasciculus | LH | 408 | 2.23 | 909.84 |
| STROOP COLOR WORD TASK | ||||
| Frontal | ||||
| Caudal middle frontal | LH | 2072 | 4.57 | 9469.04 |
| Rostral middle frontal | LH | 1780 | 3.43 | 6105.40 |
| Lateral orbitofrontal | LH | 1648 | 3.08 | 5075.84 |
| Superior frontal | RH | 1088 | 3.48 | 3786.24 |
| Precentral | RH | 960 | 3.11 | 2985.60 |
| Superior frontal | LH | 880 | 3.14 | 2763.20 |
| Precentral | LH | 836 | 3.13 | 2616.68 |
| Parietal | ||||
| Precuneus | LH | 2224 | 5.16 | 11475.84 |
| Inferior parietal | LH | 1984 | 4.49 | 8908.16 |
| Superior parietal | RH | 1048 | 3.79 | 3971.92 |
| Postcentral | LH | 736 | 3.99 | 2936.64 |
| Superior parietal | LH | 848 | 3.14 | 2662.72 |
| Temporal | ||||
| Transverse temporal | LH | 888 | 3.92 | 3480.96 |
| Middle temporal | LH | 896 | 3.60 | 3225.60 |
| Middle temporal | RH | 712 | 4.18 | 2976.16 |
| Occipital | ||||
| Lateral occipital | LH | 1824 | 4.72 | 8609.28 |
| Pericalcarine | RH | 832 | 3.12 | 2595.84 |
| Other | ||||
| Superior corona radiata | RH | 25288 | 4.83 | 122141.00 |
| Superior longitudinal fasciculus | LH | 1832 | 2.89 | 5294.48 |
| Fornix stria terminalis | RH | 1152 | 4.09 | 4711.68 |
| Splenium corpus callosum | — | 1704 | 2.41 | 4106.64 |
| Superior longitudinal fasciculus | RH | 1440 | 2.83 | 4075.20 |
| Tapetum | LH | 1080 | 3.01 | 3250.80 |
| Posterior corona radiata | RH | 1136 | 2.81 | 3192.16 |
| Superior corona radiata | LH | 1136 | 2.50 | 2840.00 |
| External capsule | LH | 776 | 3.57 | 2770.32 |
| Anterior limb of internal capsule | LH | 816 | 3.35 | 2733.60 |
| Genu corpus callosum | — | 952 | 2.24 | 2132.48 |
Clusters were defined at P < 0.05 with a cluster threshold of 320mm3 for TMT A and B and a cluster threshold of 680 mm3 for the Stroop Color Word Task. Regions were ordered by region/lobe and by weighting calculated as the product of the cluster size by the minimum P‐value (expressed as 10−x). Regional definitions were based on proximity to neural labels described in (Desikan et al., 2006; Fischl et al., 2002) and in the JHU white matter atlas. TMT A, Trail Making Test part A; TMT B, Trail Making Test part B; SCWT, Stroop Color Word Task.