Table 1.
Demographic and clinical characteristics of patients receiving a kidney allograft with or without an atherosclerotic vascular event in the first year after transplantation.
| Atherosclerotic event in the first year after kidney transplantation | P value | ||
|---|---|---|---|
| No | Yes | ||
| Number of patients | 270 | 20 | |
| Age (median and IQR in years) | 52 (40–62) | 62 (47–67) | 0.02 |
| Male gender | 69.3% | 75% | 0.59 |
| Non-Western European origin | 27.6% | 35% | 0.48 |
| CMV seropositive | 103/167 | 3/17 | 0.052 |
| Cumulative years on dialysis treatment (median and interquartile range) | 1.4 (0–3) | 1.7 (1–4) | 0.49 |
| History of atherosclerotic disease | 24.3% | 75% | <0.001 |
| Cardiovascular | 14.9% | 52.6% | <0.001 |
| Cerebrovascular | 7.9% | 25% | 0.02 |
| Aorta/peripheral arteries | 6.7% | 15.8% | 0.15 |
| Underlying kidney disease | 0.61 | ||
| Hypertensive nephropathy | 30.2% | 42.1% | |
| Primary glomerulopathy | 24.3% | 21.1% | |
| Diabetic nephropathy | 10.8% | 5.3% | |
| Polycystic kidney disease | 11.9% | 21.1% | |
| Other | 16.0% | 10.5% | |
| Unknown | 6.7% | 0.0% | |
| Prevalence of risk factors for atherosclerosis | |||
| Hypertension | 87.1% | 94.4% | 0.36 |
| Hyperlipidaemia | 43.7% | 90.9% | <0.001 |
| Smoking | 33.6% | 50.0% | 0.18 |
| Diabetes mellitus | 22.1% | 31.6% | 0.58 |
| % CD4+CD28null T cells (mean ± SD) | 5.8 ± 9.6% | 11.7 ± 13.5% | 0.01 |
| CD4+CD28null T cell × 104/mL (mean ± SD) |
25.9 ± 43.4 | 38.4 ± 46.7 | 0.23 |