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Lipinski's rule of five and *topological polar surface area (TPSA), permeability factor values of derivatives.
| Ligand | Num_H acceptors | Num_H donors | MiLog P | Number of rotatable bonds | Molecular Wt In daltons | TPSA* in Å2 |
|---|---|---|---|---|---|---|
| K | 5 | 1 | 0.104 | 1 | 248.28 | 50.804 |
| S1 | 7 | 0 | 2.056 | 3 | 402.46 | 76.157 |
| S4 | 7 | 0 | 1.608 | 3 | 388.44 | 76.157 |
| S7 | 7 | 0 | 2.892 | 3 | 457.33 | 76.157 |
| S3 | 7 | 0 | 2.286 | 3 | 422.88 | 76.157 |
