Skip to main content
. Author manuscript; available in PMC: 2013 Nov 17.
Published in final edited form as: Clin Pharmacol Ther. 2011 Nov 2;91(3):442–449. doi: 10.1038/clpt.2011.178

Figure 3. Effect of fluconazole on midazolam metabolic kinetics.

Figure 3

Representative kinetic profiles of 1’-hydroxymidazolam (A) and 4-hydroxymidazolam (B) formation by rCYP3A4 in the absence and presence of fluconazole are shown. Also shown is the altered 1’-OH-MDZ/4-OH-MDZ ratio as a function of both midazolam concentration and fluconazole concentration incubated with rCYP3A4 (C). Symbols and error bars denote means and S.E., respectively, of triplicate incubations. FLU, fluconazole.