Table 1.
Diagnostic criteria for all eligible patients with perihilar cholangiocarcinoma who were enrolled and underwent neoadjuvant therapy in anticipation for transplantation (N=199) in association with their underlying etiology and outcomes. All results are expressed in absolute numbers (N).
| Description of diagnostic criteria | N | PSC (N=127) versus De novo (N=72) | Drop-out (N=62) | Tumor on explants (N=61) | Recurrence (N=26) | |
|---|---|---|---|---|---|---|
| Definite evidence of malignancy on intraluminal brushing or biopsy (i.e. positive for adenocarcinoma) | 103 | PSC | 71 | 26 | 18 | 5 |
| De novo | 32 | 14 | 13 | 7 | ||
| Stricture + combination of 2 or more of CA 19-9>100, mass, suspicious brushing or biopsy and/or polysomy | 69 | PSC | 41 | 7 | 11 | 4 |
| De novo | 28 | 10 | 12 | 4 | ||
| Stricture + CA 19-9>100 | 6 | PSC | 3 | 1 | 1 | 1 |
| De novo | 3 | 0 | 2 | 1 | ||
| Stricture + mass | 5 | PSC | 0 | 0 | 0 | 0 |
| De novo | 5 | 2 | 2 | 2 | ||
| Stricture + polysomy | 5 | PSC | 5 | 0 | 0 | 0 |
| Stricture + suspicious brushing | 1 | PSC | 1 | 1 | 0 | 0 |
| Stricture + weight loss + obstructive jaundice | 5 | PSC | 1 | 0 | 0 | 0 |
| De novo | 4 | 1 | 0 | 1 | ||
| Diffuse strictures + CA 19-9>100 + mass | 1 | PSC | 1 | 0 | 1 | 1 |
| Diffuse strictures + suspicious brushing + polysomy | 1 | PSC | 1 | 0 | 1 | 0 |
| Intraductal polypoid lesion on ERCP + polysomy | 1 | PSC | 1 | 0 | 0 | 0 |
| Diffuse strictures + suspicious brushing + trisomy (repeatedly) | 1 | PSC | 1 | 0 | 0 | 0 |
| Diffuse strictures + polysomy | 1 | PSC | 1 | 0 | 0 | 0 |