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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: FEBS J. 2013 Apr 8;280(9):10.1111/febs.12226. doi: 10.1111/febs.12226

Fig. 4.

Fig. 4

The effect of EGFR on the CSC phenotype is mediated through β-catenin signaling. (A) In untreated CNE2 cells, β-catenin was located in cytoplasmic membranes and cytoplasm. Treatment with EGF (50 ng/mL) resulted in increased β-catenin nuclear staining, which was reversed by either gefitinib (1 μM) or LY294002 (15 μM). (B) Western blot analysis showed that elevated expression of active β-catenin, c-myc, and Nanog in response to EGF (50 ng/ml) can be reversed by either gefitinib (1 μM) or LY294002 (15 μM).