TABLE II. Sliding window based haplotypes of DRD3 markers showing significant associations in Case-control and TDT analyses.
| C-C(601/468) | Trio (n=601 ) | Addl. Trio (n=118) | Pooled Trio (n=719) | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| # | Map Information | SNP | p,df=1* | 2 – mhap , df=3 | 3 – mhap, p(df) | 4 – mhap , p(df) | 5 – mhap , p(df) | 6 - mhap, p(df) | ,df=1* | 2 – mhap (df) | 3 – mhap , p(df) | 4 – mhap , p(df) | 5 – mhap , p(df) | 6 – mhap , p(df) | ,df=1* | 2 – mhap df=3 | 3 - mhap, p(df) | 4 - mhap, p(df) | 5 - mhap, p(df) | 6 - mhap, p(df) | ,df=1* | 2 – mhap df=3 | 3 - mhap, p(df) | 4 - mhap, p(df) | 5 - mhap, p(df) | 6 - mhap, p(df) |
| DRD3 | ||||||||||||||||||||||||||
| 1 M | 115313209 | rs7631540 | 0.99 | 0.93(2) | 0.554) | 0.44(7) | 0.60(9) | 0.47(13) | 0.03 | 0.01(2) | 0.06(4) | 6×10−4(8) | 5×10− 7(13)** |
0.008(17) | 0.93 | 4×10−3(3) | 0.03(5) | 0.21(9) | 0.20(10) | 0.37(18) | 0.04 | 1×10− 4(3)** |
0.004(5) | 0.23(8) | 2×10− 4(17) |
0.01(21) |
| 2 M | 115340891 | rs2134655 | 0.92 | 0.83(2) | 0.26(4) | 0.31(5) | 0.40(11) | 0.07 | 0.11(2) | 0.03(5) | 1×10−4(9)** | 0.007(13) | 0.62 | 0.20(3) | 0.50(6) | 0.41(8) | 0.36(15) | 0.07 | 0.12(2) | 0.46(5) | 0.13(11) | 0.14(18) | ||||
| 3 M | 115352768 | rs3773678 | 0.52 | 0.14(3) | 0.16(4) | 0.40(9) | 0.13 | 0.28(3) | 1×10− 5(6)** |
7×10− 4(12)** |
0.83 | 0.89(3) | 0.07(7) | 0.25(11) | 0.15 | 0.38(3) | 0.14(7) | 0.09(13) | ||||||||
| 4 M | 115364131 | rs324030 | 0.08 | 0.29(3) | 0.31(6) | 0.26 | 4×10− 3(3) |
0.13(6) | 0.77 | 0.006(3) | 0.03(7) | 0.25 | 0.17(3) | 0.30(7) | ||||||||||||
| 5 M | 115373505 | rs6280 | 0.63 | 0.85(3) | 0.55 | 0.82(3) | 0.57 | 0.15(3) | 0.75 | 0.56(3) | ||||||||||||||||
| 6 M | 115433986 | rs905568 | 0.89 | 0.85 | 0.18 | 0.67 | ||||||||||||||||||||
C-C: case-control
Trio: family consisting of one proband and two parents
Addl. Trio: a replicate set of trio families
Pooled Trio: total of trios and addition trios
2 – mhap: two marker haplotypes generated using UNPHASED. P-values given; 3-mhap: three marker haplotypes generated using UNPHASED. P-values (degree of freedom) given. Similarly, mhap-3, -4, -5 and -6 denote haplotypes incorporating the respective number of SNPs. Haplotypes with a frequency lower than 1% were not included in the analysis.
*
p values based on analysis of individual SNPs (see Table 1).
**
p values significant after Bonferroni correction of global p value for the respective haplotype (alpha value= 0.0001 for 505 tests)