Table 4. Case–control χ ²-analysis.

													Allelic association
Gene	SNP	Subjects (n)	Genotype frequencies						HWE P-value	Allele frequencies(n (%))			P-value	OR (95% CI)
(A) Oral cleft probands vs controls
ABCB1	e12/C1236T		TT		TC		CC			T		C	0.007 (0.021)a	1.60 (1.13–2.26)
	(rs1128503)	C (189)	78		80		31		0.179	236 (0.62)		142 (0.38)
		OC (128)	68		50		10		0.848	186 (0.7)		70 (0.27)
	e21/G2677T/A		AA	AG	AT	GG	GT	TT		A	G	T	0.919	–
	(rs2032582)	C (189)	2	25	11	42	72	37	0.486	40 (0.11)	181 (0.48)	157 (0.42)
		OC (128)	0	15	9	28	51	25	0.768	24 (0.09)	122 (0.48)	110 (0.43)
	e26/C3435T		CC		CT		TT			C		T	0.889	1.02 (0.74–1.42)
	(rs1045642)	C (189)	71		86		32		0.496	228 (0.60)		150 (0.40)
		OC (128)	49		55		24		0.228	153 (0.60)		103 (0.40)
(B) Mothers of oral cleft probands vs controls
ABCB1	e12/C1236T		TT		TC		CC			T		C	0.772	1.05 (0.76–1.46)
	(rs1128503)	C (189)	78		80		31		0.180	236 (0.62)		142 (0.38)
		M (129)	53		58		18		0.739	164 (0.64)		94 (0.36)
	e21/G2677T/A		AA	AG	AT	GG	GT	TT		A	G	T	0.189	–
	(rs2032582)	C (189)	2	25	11	42	72	37	0.486	40 (0.11)	181 (0.48)	157 (0.42)
		M (129)	2	20	9	33	50	15	0.932	33 (0.13)	136 (0.53)	89 (0.35)
	e26/C3435T		CC		CT		TT			C		T	0.054	1.39 (0.99–1.94)
	(rs1045642)	C (189)	71		86		32		0.496	228 (0.60)		150 (0.40)
		M (129)	61		53		15		0.506	175 (0.68)		83 (0.32)

Abbreviations: C, control; CI, confidence interval; HWE, Hardy–Weinberg equilibrium; M, mothers; OC, oral clefts; OR, odds ratio.

P-value of <0.05 highlighted in bold.

^aBonferroni corrected.