Figure 4.

Curcumin pretreatment prevents hepatocyte apoptosis induced by acetaminophen. A: Transferase-mediated dUTP-biotin nick end labeling stained liver sections from animals treated with PBS, acetaminophen (APAP) + carboxymethylcellulose (CMC) and APAP + curcumin (CMN) (original magnification: × 400); B: Liver samples were collected 2 h and 16 h after APAP injection, and the mRNA expression of Bax and Bcl2 was determined by reverse transcriptase polymerase chain reaction. Data are expressed as mean ± SE; n = 6 mice per group. ^aP < 0.05 vs APAP + CMC.