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. Author manuscript; available in PMC: 2014 Sep 26.
Published in final edited form as: J Med Chem. 2013 Sep 9;56(18):10.1021/jm400954h. doi: 10.1021/jm400954h

Figure 2.

Figure 2

Binding modes of docked compounds in the colchicine site (colchicine: yellow; 1sa0: cyan; 3hkc: magenta). a) The two binding modes of the pyrrole compounds (2 in thick red; 7 in thick purple; other analogues depicted with thin lines); b) The binding modes of the combretastatin analogues (40, combretastatin A-4, in blue) and the pyrimidine analogues (52 in green).