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. 2013 Nov 12;4:2760. doi: 10.1038/ncomms3760

Figure 5. IA learning enhances both excitatory and inhibitory synaptic plasticity.

Figure 5

(a) Representative traces of miniature EPSCs (mEPSCs) and mIPSCs. mEPSCs at −60 mV and mIPSCs at 0 mV were measured sequentially in the same CA1 pyramidal neuron in the presence of tetrodotoxin (0.5 μM). Vertical scale bar, 20 pA; horizontal scale bar, 200 ms. (b) Plots of the mEPSC and mIPSC amplitudes in untrained, trained, unpaired and walk-through rats. Significant correlation between the mEPSC and mIPSC amplitudes in IA-trained rats was observed (P=0.037, Spearman’s rank correlation coefficient) **P<0.01 versus untrained (untrained: n=43, IA trained: n=56, unpaired: n=32, walk through: n=40, one-way factorial ANOVA followed by post hoc analysis with the Fisher’s PLSD test). Contextual learning significantly increased both mEPSC and mIPSC amplitudes. (c) Plots of the mEPSC and mIPSC frequency in untrained, trained, unpaired and walk-through rats. Contextual learning significantly increased both mEPSC and mIPSC frequencies. **P<0.01 versus untrained (untrained: n=43, IA trained: n=56, unpaired: n=32, walk through: n=40, one-way factorial ANOVA followed by post hoc analysis with the Fisher’s PLSD test). Red crosses and bars indicate mean±s.e.m.