Table 4.
Pathologic features of ROS1-altered tumors.
| Case | Specimen type | ROS1 IHC score |
ROS1 FISH status |
Dominant Histologic pattern |
Secondary pattern |
Cribriform features |
Mucinous and/or signet ring features |
Psammomatous calcification |
|---|---|---|---|---|---|---|---|---|
| 1 | Lymph node biopsy | 3+ | Negative | Solid | none | no | no | no |
| 2 | Pleural biopsy | 3+ | Rearranged | Solid | Papillary | yes | yes | no |
| 3 | Lymph node biopsy | 3+ | Rearranged | Solid | Papillary | no | no | yes |
| 4 | Brain metastatectomy | 3+ | Rearranged | Solid | Papillary | yes | yes | yes |
| 5 | Lung resection | 3+ | Rearranged | Solid | Papillary | yes | yes | yes |
| 6 | Soft tissue core biopsy | 2+ | Rearranged | Papillary | n/a | no | no | yes |
| 7 | Lung resection | 3+ | Rearranged | Solid | Papillary | yes | yes | yes |
| 8 | Lung resection | 3+ | Rearranged | Solid | Lepidic | yes | yes | yes |
| 9 | Brain metastatectomy | 3+ | rearranged | Solid | n/a | no | yes | no |