Figure 2. Selected coding variants and potential CRAC motifs in DAT.

(a) Coding variants known to alter DAT function (numbered yellow circles) and helical topological 2D architecture of DAT depicting essential cholesterol interacting residues in putative CRAC motifs (black circles with white letters). (b) Sequence alignment of human DAT, NET, and SERT showing homology within putative CRAC motifs. Residues that are key components of the motifs are shown in red; the numbers above the sequence correspond to hDAT.