Results of a logistic regression analysis to determine factors associated with the isolation of Mycoplasma bovis from nasal, joint, and lungs swabs collected at arrival, treatment, and postmortem of cattle at a southern Saskatchewan feedlot during the fall of 2007 and 2008. Cattle were allocated to receive oxytetracycline metaphylaxis on arrival to the feedlot (META) or no antimicrobials (NO-META) on arrival and by first BRD treatment of two 20 mg/kg body weight (BW) IM doses of florfenicol administered 48 h apart (HOLD) or a single 40 mg/kg BW SQ dose of florfenicol on first diagnosis (HOME). The independent variables, odds ratio, 95% confidence interval (CI), and P-values are reported