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. 2013 Oct 21;110(45):18256–18261. doi: 10.1073/pnas.1314351110

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Fig. 4. — Negative-stain EM of cleaved and uncleaved trimers. (A) Comparison of the reconstruction of the soluble BG505 SOSIP.R6 (NL) trimer (blue) (17) with the structure of the membrane-associated native Env spike of the subtype B BaL strain (mesh) (6). (B) Reference-free 2D class averages for various 2G12/SEC-purified, MPER-deleted trimers. (C) Reference-free 2D class averages for 2G12/SEC-purified SOSIP.R6-MPER, SOSIP.SEKS-MPER, and WT.SEKS-MPER trimers. (D) Reference-free 2D class averages for CN54 (subtype C) and UG37 (subtype A) uncleaved gp140s. (E) Cartoon showing the NL and AC conformations of the Env trimer (see also refs. 13 and 31).