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. 2013 Oct 21;110(45):18262–18267. doi: 10.1073/pnas.1313965110

Fig. 3.

Fig. 3.

Inhibition of gametocyte development and maturation by PfPMT inhibitors. (A and C) Diagrams of the experimental plan to determine luciferase activity immediately following removal of the compound (A) or on day 16 (C). (B and D) Heat maps representing the effect of PfPMT inhibitors on gametocyte development as measured by luciferase activity in the transgenic line NF54-pfs16-GFP-LUC. Parasites were treated for 48 h (blue bar) with 10 µM of the indicated compound at day 5, 8, or 12 following parasite inoculation. The antimalarial artemisinin (ART) was used as a control at the same concentration. (B) Luciferase activity was measured 48 h posttreatment. (D) Luciferase activity was measured at day 16. (E–G) inhibition of early (E), intermediate (F), and late (G) gametocyte development by artemisinin (A) and NSC-158011 (N). Results are the mean ± SEM of triplicate from three independent assays. Each figure is a representative of one of three independent experiments.