Fig. 4.
Reward-controlled expression of the atrial natriuretic peptide (ANP) in hypertensive mice. (A–C) Hypertensive mice were implanted with pKR147 (PCRE-ANP-pA)-transgenic HEKDRD1 (HEKDRD1-ANP) or nonengineered parental HEK-293 and either treated with dopamine injections or exposed to sexual arousal [male with (+) female company]. ANP (A), dopamine (B), and norepinephrine (C) levels were profiled in the blood of treated animals, and their systolic blood pressure was scored (D) after 48 h and compared with the blood pressure of wild-type mice. Data are mean ± SEM; statistics by two-tailed t test; n = 8 mice. *P < 0.05, ***P < 0.0001.