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ApoE4 but not ApoE3 significantly reduces sAPPα and lowers α/β ratio. A172 cells (A) and H4 cells (B) were transfected with ApoE isoforms alone or APP and ApoE isoforms, respectively. sAPPα and sAPPβ secreted into the medium and Aβ1–42 in the cell extracts were assayed as mentioned in SI Materials and Methods. Data (mean ± SE) are from four experiments performed in triplicate, *P < 0.05.
