Table 1.
Selected characteristics of 5-year cervical cancer survivors by case-control status
| Characteristic | Cases (n=201) | Controls (n=378) | ||
|---|---|---|---|---|
| N | (%) | N | (%) | |
| Registry | ||||
| Denmark (1943–1999) | 51 | (25.4) | 79 | (20.9) |
| Finland (1953–2002) | 49 | (24.4) | 97 | (25.7) |
| Iowa (1973–2001) | 1 | (0.5) | 2 | (0.5) |
| Ontario (1964–2003) | 19 | (9.5) | 38 | (10.0) |
| Sweden (1958–2002) | 81 | (40.3) | 162 | (42.9) |
| Age at cervical cancer diagnosis (years) | ||||
| 26–44 | 50 | (24.9) | 96 | (25.4) |
| 45–54 | 57 | (28.3) | 107 | (28.3) |
| 55–64 | 59 | (29.4) | 111 | (29.4) |
| 65–83 | 35 | (17.4) | 64 | (16.9) |
| Year of cervical cancer diagnosis | ||||
| 1943–59 | 52 | (25.9) | 91 | (24.0) |
| 1960–69 | 81 | (39.3) | 151 | (39.9) |
| 1970–79 | 47 | (23.3) | 99 | (26.2) |
| 1980–95 | 21 | (10.5) | 37 | (9.8) |
| Cervical cancer histology* | ||||
| Squamous cell carcinoma | 147 | (73.1) | 269 | (71.2) |
| Adenocarcinoma | 7 | (3.5) | 29 | (7.7) |
| Other and unspecified | 47 | (23.4) | 80 | (21.1) |
| Cervical cancer stage† | ||||
| I | 86 | (42.8) | 183 | (48.4) |
| II | 74 | (36.8) | 144 | (38.1) |
| III/IV | 27 | (13.4) | 41 | (10.8) |
| Localized/regional | 14 | (7.0) | 10 | (2.7) |
| Cervical cancer treatment‡ | ||||
| No radiation or chemotherapy | 9 | (4.5) | 28 | (7.4) |
| Radiation | 191 | (95.0) | 343 | (90.7) |
| Chemotherapy and radiation | 1 | (0.5) | 7 | (1.9) |
| Type of radiation | ||||
| Brachytherapy only | 17 | (8.9) | 37 | (10.6) |
| External beam only | 4 | (2.1) | 6 | (1.7) |
| Brachytherapy and external beam | 171 | (89.0) | 307 | (87.7) |
| Type of external beam energy | ||||
| Orthovoltage | 77 | (44.0) | 157 | (50.2) |
| Cobalt-60 | 31 | (17.7) | 62 | (19.8) |
| Megavoltage | 22 | (12.6) | 33 | (10.5) |
| Betatron | 16 | (9.1) | 33 | (10.5) |
| Combined energies | 12 | (6.9) | 9 | (2.9) |
| Unknown | 17 | (9.7) | 19 | (6.1) |
| Type of isotope for brachytherapy | ||||
| Radium, any | 167 | (88.8) | 307 | (89.3) |
| Cesium | 15 | (8.0) | 24 | (7.0) |
| Cobalt | 4 | (2.1) | 12 | (3.5) |
| Unknown | 2 | (1.1) | 1 | (0.3) |
| Intervel from cervical cancer to stomach cancer or comparable date for controls | ||||
| 5–9 years | 50 | (24.9) | 94 | (24.9) |
| 10–14 years | 36 | (17.9) | 68 | (18.0) |
| 15–24 years | 64 | (31.8) | 119 | (31.4) |
| 25–42 years | 51 | (25.4) | 97 | (25.7) |
| Stage of stomach cancer§ | ||||
| I + II | 33 | (16.4) | - | |
| III + IV | 89 | (44.3) | - | |
| Localized/Regional | 52 | (25.9) | - | |
| Unknown | 27 | (13.4) | - | |
| Histology of stomach cancer¶ | ||||
| Adenocarcinoma | 159 | (79.1) | - | |
| Other specified and unspecified | 42 | (20.9) | - | |
| Site of stomach cancer, grouped** | ||||
| Proximal | 30 | (14.9) | ||
| Body | 30 | (14.9) | ||
| Lesser curvature | 18 | (9.0) | ||
| Greater curvature | 8 | (4.0) | ||
| Distal | 69 | (34.3) | ||
| Entire stomach, multi-focal, anterior wall | 6 | (3.0) | ||
| Unknown | 40 | (19.9) | ||
Includes other (3 cases) and not otherwise specified (44 cases, 80 controls).
Based on the Federation of International Gynecologic Oncology (FIGO) stage. Only 1 case and 1 control were diagnosed with stage IV cervical cancer. Cervical cancer patients not staged according to the FIGO scheme were categorized as having localized (10 cases, 9 controls), localized/regional (1 case) or regional (3 cases, 1 control) disease.
No radiation or chemotherapy included hysterectomy (9 cases, 23 controls) cervical conization (4 controls) and cerviectomy (1 control).
Includes stomach cancer cases with localized (n=25), or regional (n=27) disease.
Adenocarcinoma includes 131 cases with highly likely histologic confirmation, 27 cases based on registry data only and 1 case was indeterminate. Stomach cancer histology for other specified and unspecified includes 1 sarcoma, 4 neuroendocrine malignancies, 29 not otherwise specified, and 8 based on clinical data only.
Proximal includes 20 cardia, 5 fundus, 2 stump and 3 gastroesophageal junction; body includes 29 body and 1 fundus/body; distal includes 50 antrum, 12 pylorus, 6 antrum/pylorus and 1 antrum/body; and entire stomach includes 4 entire stomach, 1 multifocal, 1 anterior wall cancer.