. Author manuscript; available in PMC: 2013 Nov 18.

Published in final edited form as: Cancer. 2010 Sep 1;116(17):10.1002/cncr.25188. doi: 10.1002/cncr.25188

Table 4.

Randomized phase III trials for anal canal cancer and the extent of prognostic factor evaluation.

	No. of Patients	Prognostic Factor Evaluation	Prognostic factors	Comments
UKCCCR⁴	585	No	None listed	No follow-up analysis
EORTC⁵	110	Yes	Gender, nodal status, and skin ulceration but not tumor diameter for DFS and OS	Small sample size
RTOG 87-04⁶	310	No	None listed	No follow-up analysis
RTOG 98-11³	644	Yes	Gender, Tumor diameter, and nodal status for DFS and OS	Four prognostic subgroups identified