Table 1.
Differences in the median concentration and proportion of specimen outside the limit of detection of cytokine markers by HR-HPV status.
| Cytokine | Total (n = 78) | Median concentration (IQR)a | p-valueb | Outside the outer range of detection N (%) | p-valuec | |||
|---|---|---|---|---|---|---|---|---|
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| Median (IQR)a | OOR N (%) | HR-HPV −ve (n = 44) | HR-HPV +ve (n = 34) | HR-HPV −ve (n = 44) | HR-HPV +ve (n = 34) | |||
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| IL-1ra | 60,590 (19,781, 158,870) | 5 (6.4) | 60,591 (24,615, 147,800) | 46,999 (16,962, 198,572) | 0.57 | 4 (9.1) | 1 (2.9) | 0.27 |
| IL-1β | 32.8 (14.8, 122.9) | 1 (1.3) | 29.1 (10.6, 115.8) | 33.8 (18.1, 129.4) | 0.22 | 0 (0) | 1 (2.9) | 0.44 |
| IL-2 | 2.2(1.3, 3.1) | 0 (0) | 2.1 (1.2, 2.9) | 2.4 (1.6, 3.3) | 0.37 | 0 (0) | 0 (0) | – |
| IL-4 | 0.12 (0.01, 0.27) | 23 (29.5) | 0.11 (0.01, 0.26) | 0.16 (0.01, 0.30) | 0.49 | 12 (27.3) | 11 (32.4) | 0.80 |
| IL-5 | 0.10 (0.06, 0.13) | 0 (0) | 0.08 (0.05, 0.12) | 0.11 (0.07, 0.16) | 0.03 | 0 (0) | 0 (0) | – |
| IL-6 | 30.9 (9.6, 106.4) | 1 (1.3) | 24.3 (9.5, 96.7) | 35.6 (11.3, 117.7) | 0.56 | 0 (0) | 1 (2.9) | 0.44 |
| IL-7 | 0.93 (0.58, 1.57) | 0 (0) | 0.82 (0.57, 1.59) | 1.03 (0.58, 1.57) | 0.72 | 0 (0) | 0 (0) | – |
| IL-8 | 921963 (956, 3066168) | 42 (53.9) | 482709 (425, 2879034) | 1129549 (2296, 3244225) | 0.25 | 23 (52.3) | 19 (55.9) | 0.47 |
| IL-9 | 2.3 (1.4, 3.7) | 0 (0) | 2.1 (1.3, 3.3) | 2.7 (1.5, 4.5) | 0.04 | 0 (0) | 0 (0) | – |
| IL-10 | 10.2 (4.8, 15.2) | 0 (0) | 8.8 (4.6, 13.1) | 10.8 (4.8, 20.6) | 0.33 | 0 (0) | 0 (0) | – |
| IL-12p70 | 8.2 (4.2, 12.2) | 0 (0) | 7.5 (4.1, 10.9) | 8.4 (4.9, 15.7) | 0.26 | 0 (0) | 0 (0) | – |
| IL-13 | 1.3 (0.3, 2.5) | 23 (29.5) | 0.9 (0.2, 1.9) | 2.1 (0.9, 3.1) | 0.01 | 16 (36.4) | 7 (20.6) | 0.10 |
| IL-15 | 5.9 (3.9, 11.2) | 0 (0) | 5.8 (3.9, 10.9) | 6.5 (4.2, 11.6) | 0.69 | 0 (0) | 0 (0) | – |
| IL-17 | 2.6 (0.7, 3.5) | 12 (15.4) | 1.1 (0.01, 3.2) | 2.9 (1.6, 4.7) | 0.003 | 11 (25.0) | 1 (2.9) | 0.01 |
| EOTAXIN | 1.5 (0.6, 4.9) | 35 (44.9) | 1.1 (0.6, 2.9) | 4.1 (0.7, 6.3) | 0.04 | 24 (54.6) | 11 (32.4) | 0.04 |
| BASICFGF | 13.9 (6.5, 17.9) | 0 (0) | 12.1 (5.7, 17.5) | 16.1 (6.6, 22.5) | 0.18 | 0 (0) | 0 (0) | – |
| GCSF | 795.7 (138.9, 3548.8) | 0 (0) | 1144.6 (207.8, 4017.9) | 579.3 (106.5, 2843.9) | 0.42 | 0 (0) | 0 (0) | – |
| GMCSF | 3.7 (2.4, 5.6) | 0 (0) | 3.3 (2.1, 4.4) | 4.3 (2.9, 6.1) | 0.01 | 0 (0) | 0 (0) | – |
| IFN-γ | 23.2 (15.4, 31.7) | 0 (0) | 22.9 (13.7, 31.4) | 23.6 (15.9, 32.9) | 0.49 | 0 (0) | 0 (0) | – |
| IP-10 | 226.2 (92, 696.2) | 0 (0) | 260.4 (100.5, 644.6) | 210.4 (66.2, 772.1) | 0.41 | 0 (0) | 0 (0) | – |
| MCP-1 | 76.7 (21.8, 172.4) | 0 (0) | 78.7 (24.9, 178) | 51.3 (19.5, 172.4) | 0.78 | 0 (0) | 0 (0) | – |
| MIP-1α | 2.7 (1.4, 4.3) | 2 (2.6) | 1.9 (1.1, 3.6) | 3.5 (2.2, 4.4) | 0.005 | 2 (4.6) | 0 (0) | 0.32 |
| MIP-1β | 64.3 (30.3, 170.8) | 5 (6.4) | 62.2 (31.7, 155.3) | 73.8 (29.6, 213.6) | 0.79 | 5 (11.4) | 0 (0) | 0.07 |
| PDGBB | 22.5 (10.4, 33.0) | 0 (0) | 21.6 (10.2, 33.5) | 22.8 (10.4, 33.0) | 0.93 | 0 (0) | 0 (0) | – |
| RANTES | 12.5 (9.1, 22.0) | 0 (0) | 11.9 (8.2, 21.2) | 12.7 (9.8, 22.0) | 0.53 | 0 (0) | 0 (0) | – |
| TNF-α | 29.9 (18.7, 39.9) | 0 (0) | 29.9 (16.4, 38.8) | 29.1 (20.9, 41.7) | 0.46 | 0 (0) | 0 (0) | – |
| VEGF | 202.7 (106.7, 386.9) | 0 (0) | 188.3 (95.9, 371) | 232.8 (107.2, 415.5) | 0.35 | 0 (0) | 0 (0) | – |
a
ng immune marker/mg total protein.
b
Wilcoxon Ranksum.
c
Fishers exact test.