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Gene-specific DNA methylation by MTHFR 677C>T genotype. Boxes represent medians and IQRs; whiskers are the expected range and outliers. A: ESR1, N33, MYOD1, and IGF2 methylation. B: APC, MGMT, and MLH1 methylation (CC, n = 185; CT, n = 119; TT, n = 32). Kruskal-Wallis tests were used for comparison between genotypes (ESR1, P = 0.92; N33, P = 0.12; MYOD1, P = 0.24; IGF2, P = 0.77; APC, P = 0.45; MGMT, P = 0.68; MLH1, P = 0.89).
