TABLE 2.
Biomarkers of folate and vitamin B-12 status by MTHFR 677C>T genotype1
| CC (n = 185) | CT (n = 119) | TT (n = 32) | P value2 | |
| Serum folate (nmol/L) | 26.1 (7.5–54.4) | 24.5 (2.5–54.4) | 25.4 (8.6–54.4) | 0.43 |
| Red blood cell folate (nmol/L) | 977 (372–2234) | 927 (406–1752) | 969 (605–2982) | 0.44 |
| Colonic tissue folate (nmol/g tissue) | 0.89 (0.14–7.53) | 0.88 (0.10–7.34) | 0.90 (0.10–5.41) | 0.91 |
| Serum vitamin B-12 (pmol/L) | 314 (89–1476) | 315 (137–1117) | 285 (123–662) | 0.51 |
| Plasma homocysteine (μmol/L) | 15.6 (1.2–37.0) | 16.2 (2.6–41.9) | 17.8 (5.9–59.4) | 0.27 |
1
All values are medians; ranges in parentheses.
2
Kruskal-Wallis tests were used to test for differences between genoytpes.