Table 3.
Variables and their distribution values used in PSA testing
| Variable | Distribution type | Mean | Source |
|---|---|---|---|
| Average number of days staying at home after consultation visit |
General (2,3,4,5,6,7; 0.05,0.05,0.15,0.2,0.3,0.25) |
5.2 |
[11] |
| Average number of days staying at home due to hospitalisation |
General (2,3,4,5,6,7; 0.05,0.02,0.02,0.25,0.25,0.05) |
4.6 |
[56] |
| Average number of days staying at home due to nosocomial rotavirus infection |
Gamma (2,1) |
2 |
[26] |
| Proportion of families with both parents working |
Normal (0.31, 0.031; truncated 0.1,0.55) |
31% |
[47] |
| Proportion seeking medical advice |
Beta general (6.5,7; 0.65,0.9) |
77% |
[1] |
| Probability of hospitalisation |
Beta general (10,5; 0.17,0.26) |
23% |
[9] |
| Probability of nosocomial infection in the first year |
Beta general (6,4; 0.01,0.048) |
3.28% |
[31-33] |
| Vaccine efficacy for mild RVGE, 1 year, 1 dose |
Normal (0.784; 0.03) |
0.784 |
[36,38] |
| Vaccine efficacy for moderate RVGE, 1 year, 1 dose |
Normal (0.808; 0.03) |
0.808 |
[36,38] |
| Vaccine efficacy for severe RVGE, 1 year, 1 dose |
Normal (0.900; 0.03) |
0.900 |
[36,38] |
| Vaccine efficacy for mild RVGE, 1 year, 2 doses |
Normal (0.871; 0.03) |
0.871 |
[36,38] |
| Vaccine efficacy for moderate RVGE, 1 year, 2 doses |
Normal (0.898; 0.03) |
0.898 |
[36,38] |
| Vaccine efficacy for severe RVGE, 1 year, 2 doses |
Normal (1.000; 0.1; truncated (0.871; 1) |
0.94 |
[36,38] |
| Age-specific incidence rate of diarrhoea |
Normal (0.023; 0.0023) |
0.023 |
|
| Vaccine coverage rate |
Uniform (0.75;1) |
87.5% |
|
| Discount rate on cost | Discrete (0,0.75,1,1.5) | 3% |
PSA probabilistic sensitivity analysis, RVGE rotavirus gastroenteritis.