Table 2.
PROSTQA Model–Predicted Probabilities of Men Having Functional Erections Suitable for Intercourse 2 Years After Radical Prostatectomy
Planned Surgical Technique |
Patient Age, y |
Pretreatment PSA Level, ng/mL |
Predicted Functional Erections After Treatment, % (95% CI) (by Pretreatment Sexual HRQOL Score)a,b |
||
---|---|---|---|---|---|
67 | 83 | 100 | |||
Nerve-sparing | 50 | ≤10 | 35 (25–45) | 52 (43–61) | 70 (61–77) |
>10 | 18 (9–34) | 32 (18–49) | 50 (32–68) | ||
60 | ≤10 | 23 (18–30) | 38 (33–44) | 57 (49–64) | |
>10 | 11 (0–21) | 21 (12–34) | 36 (22–53) | ||
70 | ≤10 | 15 (10–22) | 26 (19–35) | 43 (32–55) | |
>10 | 7 (3–14) | 13 (7–24) | 24 (13–41) | ||
Non–nerve-sparing | 50 | ≤10 | 13 (5–30) | 23 (9–46) | 39 (18–64) |
>10 | 6 (2–18) | 11 (4–31) | 21 (7–48) | ||
60 | ≤10 | 8 (3–19) | 14 (6–32) | 27 (12–50) | |
>10 | 3 (1–11) | 7 (2–19) | 13 (4–34) | ||
70 | ≤10 | 5 (2–12) | 9 (3–22) | 17 (7–37) | |
>10 | 2 (1–7) | 4 (1–12) | 8 (3–23) |
Abbreviations: HRQOL, health-related quality of life; PROSTQA, Prostate Cancer Outcomes and Satisfaction With Treatment Quality Assessment; PSA, prostate-specific antigen.
Specific values of pretreatment sexual functioning (Expanded Prostate Cancer Index Composite scores of 67, 83, and 100; range of 0–100, with a higher score representing better function) are tabulated to represent cohort distribution (25th, 50th, and 75th percentiles of scores among prostatectomy-treated patients) as well as to reflect a clinically relevant set of possible pretreatment sexual functioning. Across all treatment groups, these percentiles correspond to 358 patients (36%) with pretreatment sexual HRQOL scores of 67 or less, 441 (45%) with scores of 68–99, and 186 (19%) with scores of 100.
Individual model-predicted probabilities were calculated using the inverse logistic function {exp[X′ β]/[1 + exp(X′ β)]}, where X′ β is the sum with X representing individual characteristics observed and β representing the associated model parameter estimates for the individual characteristics in Table 1.